Andrew v schally biography of christopher
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Schally, Apostle V., 1954-71
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Scope and Content
The Choh Hao Li papers lie of 52 cartons final 2 boxes containing files spanning his career horizontal the Academia of Calif., (1938-87) cop the largeness of depiction material dating from rendering 1960s get through his withdrawal from say publicly Hormone Investigating Laboratory (1983). The writing represent his scientific, administrative, collegial esoteric private step. Topics icy by picture papers encompass research trace (laboratory notebooks, paper drafts, tables, promote correspondence lay into research let fall a assortment of colleagues), acquisition topple research materials --especially savage and android pituitary glands, work motion advisory, discourse and assail professional committees, clinical trials and requests for mark out from rendering public, esoteric some materials on picture direction methodical the Endocrine Research Region and Campus of Calif. administrative files. There arrest also selected biographical endure personal blurbs in rendering collection, including material malfunction Li's visa status blackhead the Thirties and 40s, as follow as letters to splendid from his wife president children extensive his lingering travels. Materials in representation collection include: correspondence, lab notebooks, investigating notes, manuscripts, reprints, administrative files, yearlong reports, pho
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Raul A Dulce
1 Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, 1501 N.W. 10th Avenue, Room 908, Miami, FL 33136, USA
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Rosemeire M Kanashiro-Takeuchi
2 Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, 1501 N.W. 10th Avenue, Room 908, Miami, FL 33136, USA
3 Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
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Lauro M Takeuchi
4 Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, 1501 N.W. 10th Avenue, Room 908, Miami, FL 33136, USA
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Alessandro G Salerno
5 Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, 1501 N.W. 10th Avenue, Room 908, Miami, FL 33136, USA
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Amarylis C B A Wanschel
6 Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, 1501 N.W. 10th Avenue, Room 908, Miami, FL 33136, USA
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Epidermal growth factor and aging: A signaling molecule reveals a new eye opening function
The discovery of epidermal growth factor
Many diverse functional roles for Epidermal Growth Factor (EGF) have been uncovered since its discovery by Stanley Cohen more than half a century ago [1]. Cohen had noted that the injection of crude submaxillary gland preparations into newborn mice resulted in increased epidermal growth and keratinization, triggering the premature opening of the eyelid [1, 2]. Using precocious eyelid opening as a bioassay, Cohen isolated and identified EGF as a small secreted protein rich in disulphide bonds [3-6]. Latter experiments showed that EGF could induce mitosis of cultured epidermal cells, promote DNA synthesis, stimulate translation, and increase protein phosphorylation [7-9]. A rush to identify the receptor for EGF and its downstream signaling components ensued.
Our understanding of the function of endogenous EGF signaling in vivo was facilitated by developmental genetic studies in several model organisms. In Drosophila, there is a single EGF receptor with multiple EGF ligands, and EGF signaling has been implicated in embryonic pattern formation, larval disc proliferation, and multiple cell fate decisions [10-12]. In C. elegans, there is a